Browsing by Author "Adeleye, O."

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Assessment of the antimicrobial activity of lactic acid bacteria from sorghum slurry on Clinical Strains of Diarrhoeagenic Escherichia coli
(Antibacterial activity, Diarrhoeagenic Escherichia coli, Lactic acid bacteria, Lactobacillus plantarum, Sorghum slurry., 2021) Okunye, O. L.; Okanlawon, B. M.; Idowu, P. A.; Adeleye, O.; Fasuyi, O. C.
Background: Sorghum is a nutrient-rich grain ground into flour to make different types of delicacies, and it has been reported to possess probiotic potentials. Objective: To assess the antimicrobial activity of Lactobacillus plantarum obtained from sorghum slurry on strains of enteropathogenic Escherichia coli from cases of diarrhoea. Methods: A total of 36 samples of wet-milled sorghum slurry and liquor pH were obtained and cultured on MRSA and were, after that, biochemically characterized for Lactobacillus plantarum, which was tested by agar well diffusion against 15 strains of Escherichia coli isolated from cases of diarrhoea. Results: Microbiological analysis of the 36 samples of sorghum explored produced 15 isolates of Lactobacillus plantarum. A progressive increase in acidity in relation to an increase in the period of fermentation was observed. Ninety-five per cent of the Escherichia coli strains showed resistance against some standard antibiotics. At the same time, the isolates of Lactobacillus plantarum obtained inhibited isolates of diarrhoeagenic Escherichia coli tested, showing potential usefulness of the sorghum slurry as a probiotic. Conclusion: The inhibitory activity of Lactobacillus plantarum isolated from sorghum slurry showed antimicrobial potentials that could be used for therapeutic purposes in treating diarrhoea caused by Escherichia coli, pending further investigation.
Assessment of the antimicrobial activity of lactic acid bacteria from sorghum slurry on clinical strains of diarrhoeagenic Escherichia coli.
(Dental Consultants Association of Nigeria, OOUTH, Sagamu, Nigeria, 2021) Okunye, O. L.; Okanlawon, B. M.; Idowu, P. A.; Adeleye, O.; Fasuyi, O. C.
Background: Sorghum is a nutrient-rich grain ground into flour to make different types of delicacies, and it has been reported to possess probiotic potentials. Objective: To assess the antimicrobial activity of Lactobacillus plantarum obtained from sorghum slurry on strains of enteropathogenic Escherichia coli from cases of diarrhoea. Methods: A total of 36 samples of wet-milled sorghum slurry and liquor pH were obtained and cultured on MRSA and were, after that, biochemically characterized for Lactobacillus plantarum, which was tested by agar well diffusion against 15 strains of Escherichia coli isolated from cases of diarrhoea. Results: Microbiological analysis of the 36 samples of sorghum explored produced 15 isolates of Lactobacillus plantarum. A progressive increase in acidity in relation to an increase in the period of fermentation was observed. Ninety-five per cent of the Escherichia coli strains showed resistance against some standard antibiotics. At the same time, the isolates of Lactobacillus plantarum obtained inhibited isolates of diarrhoeagenic Escherichia coli tested, showing potential usefulness of the sorghum slurry as a probiotic. Conclusion: The inhibitory activity of Lactobacillus plantarum isolated from sorghum slurry showed antimicrobial potentials that could be used for therapeutic purposes in treating diarrhoea caused by Escherichia coli, pending further investigation.
Unraveling the ethical, legal, and social implications of neurobiobanking and stroke genomic research in Africa: a studyprotocol of the African neurobiobankfor precision stroke medicine ELSI project
(Sage Publications, 2020) Akinyemi, R. O.; Jenkins, C.; Nichols, M.; Singh, A.; Wahab, K.; Akpalu, A.; Sarfo, F. S.; Owolabi, L. F.; Obiako, R.; Akinyemi, J.; Ojebuyi, B.; Adigun, M.; Musbahu, R.; Bello, A.; Titiloye, M.; Calys-Tagoe, B.; Ogunronbi, M.; Uvere, E.; Laryea, R.; Fakunle, A.; Adeleye, O.; Olorunsogbon, O.; Ojo, A.; Adesina, D.; Mensah, N.; Oguike, W.; Coleman, N.; Mande, A.; Uthman, M.; Kalaria, R. N.; Jegede, A.; Owolabi, M.; Ovbiagele, B.; Arulogun, O.
The ethical, legal, and social implications (ELSI) of emerging neurobiobanks and data resources are unclear in an African scientific landscape with unique cultural, linguistic, and belief systems. The overarching goal of the African Neurobiobank for Precision Stroke Medicine–—ELSI Project is to identify, examine, and develop novel approaches to address ELSI issues of biobanking and stroke genomic research in sub-Saharan Africa (SSA). To accomplish the goal we will (1) explore knowledge, attitude, perceptions, barriers, and facilitators influencing ELSI issues related to biobanking and stroke genomic research; (2) use information obtained to craft a community intervention program focused on ELSI issues; and (3) build capacity and careers related to genomics and biobanking for effective client/community engagement while enhancing regulatory, governance, and implementation competences in biobanking science in SSA. A community-based participatory research and mixed-methodological approach, focused on various levels of the social ecological model, will be used to identify and examine relevant ELSI issues. Contextual intervention tools, platforms, and practices will be developed to enhance community understanding and participation in stroke biobanking and genomics research activities while facilitating enduring trust, and equitable and fair utilization of biobanking resources for genetic and trans-omics research. A concurrent capacity building program related to genetic counseling and biobanking will be implemented for early career researchers. The huge potential for neurobiobanking and genomics research in Africa to advance precision medicine applicable to stroke and other neurological disorders requires addressing ELSI challenges while building sustainable research, career, and regulatory capacities in trans-omics and biobanking science.