Browsing by Author "Adewumi, M. A."

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    Effect of tenofovir, an antiretroviral drug, on hepatic and renal functional indices of Wistar rats: protective role of vitamin E
    (Walter de Gruyter GmbH (De Gruyter), 2012) Adaramoye, O. A.; Adewumi, M. A.; Adesanoye, O. A.; Faokunla, O. O.; Farombi, E. O.
    Tenofovir (TFR) is a nucleotide reverse transcriptase inhibitor with activity against human immunodeficiency virus. We studied the effect of TFR administered to Wistar rats on hepatic and renal function markers and the possible modulatory role of vitamin E (Vit E). The study consists of four groups of six rats each. The fi rst group served as control, the second group received TFR at 50 mg/kg/day for 4 weeks, third group received TFR and Vit E, and the last group received Vit E alone. TFR administration caused a significant (p< 0.05) increase in the levels of serum urea, creatinine, urinary glucose, and protein by 65 % , 51 % , 88 % , and 79 % , respectively, relative to controls. This was followed by a signifi cant (p< 0.05) reduction in creatinine clearance of TFR-treated rats. There were no significant differences (p > 0.05) in the activities of serum aminotransferases,, glutamyl transferase and alkaline phosphatase in TRF-treated rats relative to controls. TFR administration caused a marked elevation of malondial dehyde (MDA; index of lipid peroxidation) in the animals. Specifi cally, serum, hepatic, and renal MDA levels increased by 75 % , 90 % , and 102 % , respectively. TRFtreated rats had signifi cantly (p < 0.05) reduced activities of renal catalase, glutathione- S -transferase, and superoxide dismutase. Supplementation of Vit E ameliorated TFR-induced effects by decreasing the levels of MDA and enhancing the activities of renal antioxidative enzymes. The biochemical data were supported by histopathological fi ndings from the slides.TFR increased oxidative stress and altered kidney function markers in the rats, whereas supplementation of Vit E attenuated these effects.
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    Seroprevalence Of Infectious bursal disease virus In Local Chickens In Udu Local Government area Of Delta State, South East Nigeria
    (Taylor & Francis, 2015) Abraham-Oyiguh, J.; Adewumi, M. A.; Onoja, A. B.; Suleiman,I.; Sulaimand, L. K.; Ahmed, S. J.; Jagboro, S. T.
    Infectious Bursal Disease Virus (IBDV) poses a great global threat to the poultry industry. Knowledge of the occurrence of the disease is important in the design and implementation of acontrol program, therefore this study determines the seroprevalence of IBDV in local chickens in Udu Local Government Area of Delta State. 250 chickens were bled by exsanguination and sera obtained were screened using Agar Gel Immunodiffusion (AGID) test. The seropositivity was 51.6%, which is indicates endemicity of the disease. Biosecurity and good sanitary measures are recommended. Molecular characterization of the strains should be carried out for inclusion in generic vaccines.