Browsing by Author "Awodele, O. A."

Now showing 1 - 3 of 3

Comparative performance and haematological profile of cockerel chickens debeaked at varied length and at different ages
(Nigerian Society for Animal Production, 2017) Bolarinwa, M. O.; Adeyemo, G. O.; Awodele, O. A.
An experiment was conducted to determine the comparative performance of cockerel chickens debeaked at varied length and at different ages. One hundred and ninety-five cockerel birds were purchased from a reputable hatchery, brooded and randomly allotted into 4 treatments of three replicates and 15 birds per replicate. Treatment 1 (T1) served as the control which contained 15 birds that were allotted into 3 replicates without debeaking. At the 4th week, 45 birds were debeaked at varied degrees of debeaking to form treatments 2, 3 and 4 respectively as follows: T2- ½ of upper beak and ½ of lower beak debeaked using 5 birds per replicate and 3 replicates per treatment. T3- 1/3 of upper beak and ½ of lower beak debeaked using 5 birds per replicate and 3 replicates per treatment and T4- 1/3 of upper beak and ½ of lower beak were debeaked using 5 birds per replicate and 3 replicates per treatment as it was done in all other treatments. Also, the same procedures used for all the treatments, in the 4th week as demonstrated above were repeated in the sixth, eighth and tenth week of age respectively so as to reflect the treatment effect at different ages. Data collected include: initial and final weight, daily feed intake, body weight gain and of haematological parameters. Results showed that varied degrees of debeaking examined significantly affected (p< 0.05) all the performance parameters considered: body weight gain, FCR, heterophil/lymphocyte ratio etc. It was therefore concluded that farmers should imbibe the practice of cutting half of the upper beak and half of the lower beak or one third of the upper beak and half of the lower beak (T2) preferably at the earlier stages of the birds' life as they gave better values for the performance parameters considered.
Fluoride‑induced hepatotoxicity is prevented by L‑Arginine supplementation via suppression of oxidative stress and stimulation of nitric oxide production in rats
(Springer, 2021) Akinrinde, A. S.; Tijani, M.; Awodele, O. A.; Oyagbemi, A. A.
Objective Concerns over fluoride toxicity have increased in recent times due to high exposures from various anthropogenic sources such as industrial sites, fluoride-containing pesticides, drugs, dental products, refridgerants and fire extinguishers. There is, therefore, continued search for agents that could ameliorate the toxicity of this chemical in various body organs. In this study, we sought to investigate the protective effects of L-Arginine (L-Arg), a nitric oxide donor, on liver toxicity induced by sodium fluoride (NaF) in rats. Methods Rats received NaF (300 mg L−1) in drinking water alone or in co-treatment with L-Arg at two different doses, 100 and 200 mg kg−1, by oral gavage, for 7 days. Markers of hepatotoxicity, oxidative stress and antioxidant status were thereafter assessed. Results NaF caused marked increase in serum transaminases: alanine aminotransferase, Aspartate aminotransferase and Alkaline phosphatase, along with atrophy of the centri-lobular hepatic cords and dilatation of the sinusoids. Moreover, NaF stimulated increases in hepatic contents of hydrogen peroxide (H2O2), nitric oxide (NO), protein carbonyls, malondialdehyde and advanced oxidation protein products. NaF also inhibited the activities of antioxidant enzymes, Glutathione peroxidase and Superoxide dismutase. However, L-Arg supplementation caused significant alleviation of NaF hepatotoxicity by reducing lipid and protein oxidation indices, stimulation of antioxidant systems along with increased production of NO. Conclusions L-Arg showed promise as a potential protective agent against NaF-induced hepatotoxicity via restoration of oxidant-antioxidant balance. Further studies are required to understand the involvement of NO signaling in the protective effects of L-Arg against fluoride toxicity.
The retrospective study of small animal cases presented to the Veterinary Teaching Hospital, University of Ibadan, Ibadan, 2009–2013
(Scholarena / Independent academic publisher, 2022) Ajibade, T. O.; Awodele, O. A.; Tijani, M. O.; Adejumobi, O. A.; Adetona, M. O.; Oyagbemi, A. A.; Adedapo, A. D.; Omobowale, T. O.; Aro, A. O.; Ola-Davies, O. E.; Saba, A. B.; Adedapo, A. A.; Nkadimeng, S. M.; Mc Gaw, L. J.; Kayoka-Kabongo, P. N.; Oguntibeju, O. O.; Yakubu, M. A.