Browsing by Author "Babayemi, D.O."

Now showing 1 - 2 of 2

Co-administration of sodium selenite and sodium arsenite exacerbates hepatic, renal, pulmonary and splenic inflammation in rats
(Elsevier, 2021) Adeyi, O.E.; Babayemi, D.O.; Ajayi, B.O.; Adeyi, A.O.; Ayodeji, A.H.; Oguntayo, A.O.; Adeyemi, A.T.; Olaiyapo, O.E.; Adeoye, S.T.
This study examined the effect of co-administration of sodium selenite (SS) and sodium arsenite (SA) on inflammation in rats. Thirty (30) male Wistar rats were separated into 6 groups of five animals each. Group I (control) was given distilled water, groups II, III, IV and V were exposed to 20 and 40 ppm SA in drinking water, but in addition to that, groups IV and V only were co-exposed with 0.25 mg/kg bwt SS, while group VI was exposed to 0.25 mg/kg bwt SS only orally. Following 5 weeks of exposure, levels of pro-inflammatory cytokines (TNF- α, IL-1 βand IL-6) were increased in SA-exposed groups. Synergistic and antagonistic effects were observed in co-exposed groups depending on dose and the spe- cific tissue being considered. Synergism was observed in tissues co-exposed to higher dose (40 ppm) of SA + 0.25 mg/kgbwt SS except in the liver, where these markers were de- creased compared with control. Level of IL-10 (anti-inflammatory marker) decreased in all the tissues investigated except in the lungs of animals co-exposed with 40 ppm SA. There was alteration in tissue architecture, revealing steatosis and hemorrhagic lesions as the common features in co-exposed groups. Results obtained indicate that the dose of SS used in this study may be toxic and not therapeutic against SA-induced tissue inflammation in rats.
Sub-acute Exposure to Sodium Selenite-induced Dyslipidemia, ATPase-independent Electrolytes Disruption and Tissue Damage in Male Wistar Rats
(Nigerian Society for Experimental Biology, 2020) Adeyi, O.E.; Babayemi, D.O.; Ugwor, E.I.; Adeyi, A.O.; Afolabi, A.F.; Popoola, G.A.; Oyelami, S.O.
Selenium (Se) is a trace element required for many cellular functions in most organisms although also known to be toxic, has a narrow range separating chronic conditions of deficiency and toxicity. This study investigated the effects of exposure to different doses of Se as sodium selenite on some biochemical markers in male albino rats. Twenty-four rats grouped into four with six animals each were used. One of the groups served as control given distilled water and the other three groups were respectively given 16, 32, and 64 ppm Se orally in their drinking water for 4 weeks. Animals were sacrificed thereafter, blood and tissues were collected, and biochemical parameters carried out using spectrophotometric method. In the plasma of exposed animals, activities of both aspartate and alanine transaminases (AST and ALT) were significantly increased while significant decrease in albumin and direct bilirubin levels were observed when compared to control. Exposure to Se also resulted in decreased levels of HDL triacylglycerol (TAG) and cholesterol (Chol), while increasing those of VLDL + LDL. In the tissues, TAG levels were decreased while hepatic Chol level increased. Furthermore, Se disrupted electrolyte homeostasis in the different compartments studied independent of the ATPases. These results thus point out some of the cellular alterations caused by sodium selenite exposure and may proffer biochemical basis for some of the clinical manifestations of selenium toxicity.