Browsing by Author "Coker, A. O."

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Assessment of serological markers of genital chlamydia trachomatis infection among the gynaecology patients attending Babcock University teaching hospital, Ilishan-Remo, Ogun state, Nigeria.
(2019) Ajani, T. A.; Elikwu, C. J.; Nwadike, V.; Babatunde, T.; Anaedobe, C. G.; Opeoluwa S.; Okangba, C.; Oluwasola, T. A. O.; Omeonu, A.; Faluyi, B.; Thompson, T. E.; Ebeigbe, E.; Ajani, M. A.; Joshua, A. K.; Kolawole, T.; Kristilere, H.; Meremikwu, C. M.; Mgbemena, L.; Nwaejike, C. S.; Salami, A.; Tantua, A.; Timothy, M.; Akagbusum, T.; Coker, A. O.
Genital Chlamydia trachomatis infection causes significant morbidity and mortality in women. A number of epidemiologic studies have suggested that Polymerase Chain Reaction (PCR) is more accurate as a diagnostic tool for Chlamydia trachomatis.However, the use of serological markers may be cost effective and practical in diagnosing and estimating the burden of the disease in resource limited countries.This study was aimed at determining the serological markers (IgG, IgM and IgA) of Chlamydia trachomatis, evaluate the association between Chlamydia trachomatis infection and the sociodemographic characteristics and clinical diagnosis of the participants. This was a cross sectional hospital-based study in which blood samples from 145 consenting participants were tested for IgG, IgM and IgA antibodies against Chlamydia trachomatis using enzyme linked immunosorbent assay and their clinical diagnosis, retrieved from their case notes. The cumulative prevalence of seropositivity for Chlamydia trachomatis (IgG, IgM, IgA) was 112 (77.2%) while 33 (22.8%) were seronegative. The overall predominant seromarker was IgG 91(62.8%) while IgM and IgA accounted for 85(58.6%) and 54(37.2%) respectively. A statistically significant association was found between Chlamydia trachomatis infection and PID (p value = 0.031), primary infertility (p value 0.011) and level of income (p value= (0,045).
Nasal carriage of methicilliin resistant staphylococcus aureus in livestock and farmworkers in Two Communities in Lagos, Nigeria
(Israel Veterinary Medical Association (IVMA), Raanana, Israel, 2019) Adesida, S. A.; Oke, A.-O. O.; Amosun, E. A.; Coker, A. O.
The epidemiology of methicillin resistant Staphylococcus aureus (MRSA) is dynamic and thè associated public health risk is likely to increase in settings where there is dose interaction between humans and animals.This study assessed thè occurrence of antimicrobial resistance among S. aureus from livestock and farm personnel, and estimated methicillin-resistance among thè isolates.Two hundred and fifty (250) nasal specimens were collected ffom sheep, goats, cows and farm personnel who had contact with thè animals in two farms in a sub- urban region within Lagos State. Antibiotic susceptibility test was performed using disk diffusion method. The presence of mecA and mecC gene was determined by PCR. S. aureus was recovered from 141 (56.4%) of thè 250 nasal samples analyzed: 32 (22.7%) from cows, 25 (17.7%) from sheep, 32 (22.7%) from pigs, 24 (17.0%) from goats and 28 (19.9 %) from farm workers. Ten isolates, consisting of 4 from cows (8%), 3 from pigs (6%), and 3 from farm personnel (6%), were positive for MRSA. The human-MRSA were recovered from pig workers (2) and a cow farm worker (1). All MRSA strains were resistant to at least three different antimicrobial categories. The MSSA strains were dassified into thirteen antibiotypes of various subtypes. mecC- MRSA was not detected. The high frequency of S. aureus with phenotypic multidrug resistance traits encountered in this study presents a major public health issue. Thus, practices directed at minimizing thè burden of antimicrobial resistance in farm animals should be initiated.
Problem identification and needs assessment for healthcare technologies
(University of Cape town, 2019-07) Saidi, T.; Ajibola, O. O. E.; Desmennu, A.; Ojebuyi, B. R.; Oladapo, O. A.; Tade, O.; Achi, C. G.; Balogun, O. J.; Nwaneri, S. C.; Aiyegbusi, A. I.; Umesi, D. C.; James, A. B.; Coker, A. O.; Achenbach, C. J.
Seasonal variations in pm2g air pollutants and impact on preterm birth rate in Kampala: A Retrospective Cohort
(Nigerian Society of Engineers Ibadan (Premier) Branch, 2020) Ajaelu, C. S.; William, w.; Akintayo, F.O.; Coker, A. O.
There is a growing body of evidence linking air pollution to negative births outcomes, but few studies have explored the relationship of air pollution on negative births outcomes such as preterm birth in Africa. Identifying the association between PM2 5 and preterm births will be a good starting point for intervention and policy changes on air pollution reduction methods. The study aimed to determine the association between seasonal variation in PM25 and preterm births in Kampala Uganda. Retrospective cohort study was carried out by collecting birth outcomes data from District Health Information System 2 (DHIS2) database, with the authority of Kampala Capital City Authority (KCCA). PM2.5 data were collected from US Embassy monitoring station from January 2018 to December 2019. Association between seasonal variation in PM2.5 and preterm births were found using STATA 13.0 version. This study showed a seasonal trend in PM2.5 level which was very high between the range of 56-72 ugym1 in the two dry seasons of the year 2018 and 2019. It was found lower in both wet seasons of the year 2018 and 2019 within the range of 40-52 pg/m3. The regression analysis showed that there is a strong association between each 10 unit increase in PM2.5 and preterm births in second dry season of 2018 and the first dry season of 2019 (p<0.000). The results of this study support with evidence the relationship between PM2.5 air pollutant and preterm births, especially in dry seasons