Browsing by Author "Famuyiwa, O. I."

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Association of the ABO blood group with SARS-CoV-2 infection in a community with low infection rate
(International Society of Blood Transfusion, 2021) Kotila, T. R.; Alonge, T. O.; Fowotade, A.; Famuyiwa, O. I.; Akinbile, A. S.
Background and objectives Reports on the association of the ABO phenotypes with infection by the SARS-CoV-2 virus have mostly come from countries with high infection rates. This study examined the possible association between SARS-CoV-2 infection and the ABO phenotype in Black Africa. Materials and methods This report is from a single centre where both asymptomatic and symptomatic patients were quarantined. At the time of this report, Oyo State, Nigeria had carried out 15 733 tests of which 3119 were positive for the virus with 1952 recoveries and 37 deaths. The ABO distribution of patients was compared with that of a blood donor population. Results Of the 302 participants, 297 (98%) had their blood group determined, asymptomatic and symptomatic individuals were 123 (40_7%) and 179 (59_3%) respectively. Blood group O was significantly less represented among the patients (P < 0_01) while blood groups B and AB were significantly more represented (P < 0_01, P = 0_03 respectively). Patients with anti-B (groups A and O) were significantly less represented than those without anti-B (B and/or AB): B and AB (P < 0_001), B (P = 0_002), AB (P = 0_01). There was no difference in the blood group distribution of symptomatic and asymptomatic patients (v2 (3, N = 302) = 2_29; P = 0_51), but symptomatic patients with anti-A (groups B and O) were more represented than asymptomatic patients with anti-A (v2 4_89; P = 0_03). Conclusion The higher prevalence of blood group O and more potent beta haemolysins (anti-B antibodies) are likely reasons for the lower infectivity by the SARS-CoV-2 virus and severity of COVID-19 disease in the community.
Haemocytometric profile of Nigerian patients with Covid-19
(Faculty of Basic Mdical Sciences, University of Ibadan, 2021) Arinola, O. G.; Edem V. F.; Rahamon, S. K.; Fowotade, A.; Onifade, A. A.; Adekanmbi, O. B.; Salami, O. I.; Fashina, O. A.; Ishola, O. C.; Akinbola, I. O.; Akinbile, A. S.; Eegunjobi, O. A.; Bello, M. D.; Famuyiwa, O. I.; Olaoti, A. J.; Olaniyan, O. A.; Oke, C. A.; Johnson, O. J.; Fagbemi, S. O.; Alonge, T. O.
The haemocytometric changes and possible interplay with duration of hospital stay, gender and age in Nigerians with COVID-19 were determined in this study. Routine haemocytometry was evaluated using a standard method and thereafter, neutrophil-lymphocyte ratio (NLR); a marker of inflammation was calculated. Neutrophil percentage, total white blood cell (WBC) count and NLR were significantly higher while lymphocyte percentage was significantly lower in patients with COVID-19 compared with the controls. In females with COVID-19, neutrophil percentage was significantly higher compared with the males. Considering length of hospital stay, monocyte percentage was significantly higher in patients who spent more than 10 days on admission compared with those with 10 or fewer days of admission. At discharge, the proportion of patients with monocyte percentage above the reference range was significantly lower compared with baseline. Also, monocyte percentage in COVID-19 patients had significant positive correlation with days on admission. Alteration in haemocytometry worsens with increasing age as percentages of monocyte and neutrophil, NLR and WBC count were significantly higher while the lymphocyte percentage was significantly lower in patients aged 40 years and above compared with younger patients. Also, age had significant positive correlation with percentages of monocyte and neutrophil, NLR and WBC count but a significant negative correlation with lymphocyte percentage. Haemocytometric changes and inflammation in COVID-19 patients increase with age. Also, monocyte count could be an indicator of longer hospital stay and its reduction might be an indicator of recovery from the disease.