Browsing by Author "Kehinde, A. O."

Now showing 1 - 6 of 6

Comparative study of methods of diagnosis of Helicobacter pylori infection in Ibadan
(Society for Gastroenterology and Hepatology in Nigeria, 2011) Oluwasola, A. O.; Okolo, C. A.; Otegbayo, J. A.; Adeniyi, B.; Kehinde, A. O.; Akere, A.; Ola, S. O.; Lawal, T. O.; Idowu, P. A.; Odaibo, G.; Lawan, A. I.
Comparative study of methods of diagnosis of Helicobacter pylori infection in Ibadan, Nigeria
(Medknow, 2011) Oluwasola, A. O.; Okolo, C. A.; Otegbayo, J. A.; Adeniyi, B.; Kehinde, A. O.; Akere, A.; Ola, S. O.; Lawal, T. O.; Idowu, P. A.; Odaibo, G.; Lawan, A. I.
Background &Objective: Diagnostic tests currently in use for the detection of Helicobacter pylori have been classified into either non-invasive or invasive categories, with each having its merits and demerits, as well as superiority over the other depending on the clinical setting. This study compared the accuracy of the urea breath test, histology, serology and stool antigen assay using culture as the gold standard in the diagnosis in our clinical setting. Method: Blood, stool, fibre-optic endoscopic gastric biopsies and breath were tested in 52 consenting dyspeptic patients for the detection of H. pylori infection. Results: The Negative Predictive Values, Positive Predictive Values and the diagnostic accuracy obtained were 40%, 73.7%, 47.1%; 8.3% 80.6%, 62.5%; 12.5%, 94.1%, 68%; and 30%, 93.8%, 69% for Faecal antigen test, Serology, Histology and Urea breath test respectively. Conclusion: Our findings show that histology is reliable for definitive diagnosis of H. pylori infection in dyspeptic patients in our setting and where facilities are available; UBT can be used as a non-invasive method of assessment of eradication of infection.
Prevalence of Helicobacter pylori infection among dyspepsia patients in Ibadan, South West Nigeria
(Academic Journals, 2012) Adeniyi, B. A.; Otegbayo, J. A.; Lawal, T. O.; Oluwasola, A. O.; Odaibo, G. N.; Okolo, C.; Ola, S. O.; Idowu, P. A.; Akere, A.; Kehinde, A. O.
Helicobacter pylori infection is typically acquired shortly after birth in both low and high-income regions of the world and once the infection is established, it commonly persists lifelong unless treated. This infection has been identified as an important risk factor for the development of peptic ulcer disease and is probably the most important cause of relapse in those previously treated for peptic ulcer disease. The aim of this study was to determine the prevalence of H. pylori infection in patients with peptic ulcer disease at the University College Hospital (UCH) Ibadan; South West Nigeria. Fifty-two (52) patients who had symptoms of dyspepsia were recruited for the study and each of them went through endoscopy. Forty-three (43) (82.7%) of the patients were diagnosed with peptic ulcer disease while nine (9) (17.3%) patients were diagnosed normal. The presence of H. pylori was determined using culture and Urease Breath Test (UBT). The culture result showed that thirty-five (35) (81.4%) of the patients diagnosed with peptic ulcer disease had H. pylori infection also, eight (8) (88.9%) of the normal patients were culture positive for H. pylori. The UBT result showed that 65.1% of the diagnosed peptic ulcer patients were positive for H. pylori, also 55.6% of the normal patients were found UBT positive for H. pylori. In all, H. pylori infection is very common among dyspepsia patients and the organism is closely associated with the disease in South West Nigeria.
Prevalence of Helicobacter pylori infection among dyspepsia patients in Ibadan, South West Nigeria
(Academic Journals, 2012) Adeniyi, B. A.; Otegbayo, J. A.; Lawal, T. O.; Oluwasola, A. O.; Odaibo, G. N.; Okolo, C.; Ola, S. O.; Idowu, P. A.; Akere, A.; Kehinde, A. O.
Helicobacter pylori infection is typically acquired shortly after birth in both low and high-income regions of the world and once the infection is established, it commonly persists life long unless treated. This infection has been identified as an important risk factor for the development of peptic ulcer disease and is probably the most important cause of relapse in those previously treated for peptic ulcer disease. The aim of this study was to determine the prevalence of H. pylori infection in patients with peptic ulcer disease at the University College Hospital (UCH) Ibadan; South West Nigeria. Fifty-two (52) patients who had symptoms of dyspepsia were recruited for the study and each of them went through endoscopy. Forty-three (43) (82.7%) of the patients were diagnosed with peptic ulcer disease while nine (9) (17.3%) patients were diagnosed normal. The presence of H. pylori was determined using culture and Urease Breath Test (UBT). The culture result showed that thirty-five (35) (81.4%) of the patients diagnosed with peptic ulcer disease had H. pylori infection also, eight (8) (88.9%) of the normal patients were culture positive for H. pylori. The UBT result showed that 65.1% of the diagnosed peptic ulcer patients were positive for H. pylori, also 55.6% of the normal patients were found UBT positive for H. pylori. In all, H. pylori infection is very common among dyspepsia patients and the organism is closely associated with the disease in South West Nigeria.
Seroprevalence of hepatitis E among restaurant food handlers in Ibadan, Nigeria
(National Institute for Medical Research (NIMR), 2019) Fowotade, A.; Akande, O.; Gbaja, A. T.; Ogunleye, V. O.; Ajayi, A.; Kehinde, A. O.
Background: Hepatitis E virus (HEV) is one of the causative agent of acute viral hepatitis in humans. HEV is an important public health disease in many parts of the world because it is transmitted faeco-orally. Majority of the documented studies on hepatitis E virus in Nigeria have focused on pregnant women and animal handlers with limited data among food handlers. Thus the current study aimed at investigating the prevalence of HEV infection among food handlers operating within the premises of a tertiary care facility. Methods: One hundred and seventy seven (177) food handlers were screened using commercial Enzyme- Linked Immuno-Sorbent Assay (ELISA) to detect IgM antibodies to Hepatitis E. A semi-structured questionnaire was used to assess risk factors for HEV infection. Results: HEV IgM antibodies were detected in 16 (9.0%) of the participants. Age-specific HEV IgM seroprevalence appeared to decrease with age, however there were no significant differences in HEV IgM seropositivity regarding age (P=0.251), gender (P = 0.231), marital status (P=0.735) and religion (P = 0.906). Significant risk factors for HEV IgM seropositivity included source of water for drinking (P=0.03) and the use of soap for hand washing (P=0.02). Conclusion: Our findings suggest that HEV remains a public health problem, as the virus circulates at low but considerable levels especially among food handlers; thus posing a threat to potential contacts. Proper hand washing practices as well as provision of portable water are important factors for the control of Hepatitis E.
Sexually transmitted infections
(General Studies Programme, University of Ibadan, 2012) Kehinde, A. O.; Adesina, B.