Browsing by Author "Kuti, K. M."

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    Effect of text messaging plus peer navigation on viral suppression among youth with HIV in the icare Nigeria pilot study
    (Wolters Kluwer Health, 2021) Taiwo, B. O.; Kuti, K. M.; Kuhns, L. M.; Omigbodun, O.; Awolude, O.; Garofalo, R.; Johnson, A. K.; Adeyemi, O.; Berzins, B.; Olaleye, O.; Adepoju, O.; Adeniji, J. A.; Adewumi, O. M.; Hirschhorn, L. R
    Background: Consistent with the global trend, youth with HIV (YWH) in Nigeria have high rates of viral nonsuppression. Hence, novel interventions are needed. Setting: Infectious Diseases Institute, College of Medicine, University of Ibadan, Nigeria. Methods: In a single-arm trial, participants aged 15–24 years received 48 weeks of a combination intervention, comprising daily 2-way text message medication reminders plus peer navigation. The primary outcome measure was viral suppression less than 200 copies/mL. The secondary outcome measures included self-reported adherence on avisual analog scale and medication possession ratio, each dichotomized as $90% (good) or ,90% (poor) adherence. The outcomes were analyzed using McNemar test. Retention in care, intervention feasibility and acceptability, and participants’ satisfaction were also assessed. Results: Forty YWH (50% male participants) were enrolled: meanage 19.9 years (SD = 2.5), 55% perinatally infected, and 35% virologically suppressed at baseline. Compared with baseline, the odds of virologic suppression was higher at 24 weeks (odds ratio = 14.00, P , 0.001) and 48 weeks (odds ratio = 6.00, P = 0.013). Self-reported adherence ($90%) increased from baseline at 24 weeks (63%, P = 0.008) and 48 weeks (68%, P = 0.031). Medication possession ratio $90% increased at weeks 24 and 48 (85% and 80%, respectively), achieving statistical significance at 24weeks alone (P = 0.022). Retention in care at 48 weeks was 87.5%. All (37/37) participants at week 48 were fully or mostly satisfied with the intervention. Conclusion: Daily 2-way text message reminders plus peer navigation is a promising combination intervention to improve viral suppression among YWH in Nigeria.
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    HCV co-infection is associated with metabolic abnormalities among HAART naïve HIV-infected persons
    (2017) Kuti, M. A.; Akinyemi, J. O.; Ogunbosi, B. O.; Kuti, K. M.; Adesina, O. A.; Awolude, O. A.; Michael, O. S.; Adewole, I. F.
    Objectives: To determine the metabolic abnormalities among Hepatitis C Virus (HCV) coinfected HAART naïve HIV infected persons within the adult ARV clinic of the University College Hospital/University of Ibadan, Ibadan, Nigeria Methods: This was a retrospective study involving the review of clinical records of newly recruited HIV-infected persons in the adult antiretroviral (ARV) clinic over a 12month period (January - December 2006). Baseline results for fasting plasma glucose (FPG) and fasting lipid profile were retrieved. Results: Out of the 1,260 HIV infected persons seen during the study period, HCV co-infection was found in 75 (6%) persons. The median values for total cholesterol, LDL-cholesterol and HDLcholesterol were lower in the HCV co-infected persons. HIV-HCV co–infection was associated with a 0.31 mmol/L depression in Total Cholesterol (TC). The median FPG concentration was significantly higher in HIV-HCV co–infected than HIV only infected persons (5.33mmol/L vs. 5.00mmol/L, p = 0.047). However, regression analysis showed there was no relationship between the HIV-HCV coinfected State and fasting glucose levels. Conclusion: HIV-HCV co-infection may be associated with a predictable decline in plasma cholesterol, but FPG may not be sufficient to demonstrate insulin resistance in these persons.