Browsing by Author "Nweke, M."

Now showing 1 - 3 of 3

Gender differential in inclination to donate brain for research among Nigerians: the IBADAN Brain Bank Project
(Springer Nature, 2019) Akinyemi, R.; Ojagbemi, A.; Akinyemi, J.; Salami, A.; Olopade, F.; Farombi, T.; Nweke, M.; Uvere, E.; Aridegbe, M.; Balogun, J.; Ogbole, G.; Jegede, A.; Kalaria, R.; Ogunniyi, A.; Owolabi, M.; Arulogun, O.
Background: Laboratory-based studies of neurological disease patterns and mechanisms are sparse in sub-Saharan Africa. However, availability of human brain tissue resource depends on willingness towards brain donation. This study evaluated the level of willingness among outpatient clinic attendees in a Nigerian teaching hospital. Methods: Under the auspices of the IBADAN Brain Bank Project, a 43—itemsemi-structured interviewer—administered questionnaire was designed to evaluate knowledge, attitude, and beliefs of individuals attending Neurology, Psychiatry and Geriatrics Outpatient clinics regarding willingness to donate brain for research. Association between participants characteristics and willingness towards brain donation was investigated using logistic regression models. Analysis was conducted using Stata SE version 12.0. Results: A total of 412 participants were interviewed. Their mean age was 46.3 (16.1) years. 229 (55.6%) were females and 92.5% had at least 6 years of formal education. Overall, 109 (26.7%) were willing to donate brains for research. In analyses adjusting for educational status, religion, ethnicity, marital status and family setting, male sex showed independent association with willingness towards brain donation OR (95% CI) 1.7 (1.08–2.69), p = 0.023. Participants suggested public engagement and education through mass media (including social media) and involvement of religious and community leaders as important interventions to improve awareness and willingness towards brain donation. Conclusion: The survey revealed low willingness among outpatient clinic attendees to donate brain for research, although men were more inclined to donate. It is imperative to institute public engagement and educational interventions in order to improve consent for brain donation for research.
Histopathologic pattern of posterior cranial Fossa tumours in a West African tertiary
(Zambia Medical Association, 2019) Salami, A.; Adeleye, A.; Oyemolade, T.; Ajani, M.; Usiholo, A.; Nweke, M.; Adeolu, A
Introduction: The posterior cranial fossa contains many vital structures and mortality of patients with tumours occurring in this area is high. Studies done in other geographic locations showed a higher occurrence of posterior cranial fossa tumours in paediatric patients while benign tumours were more commonly seen. Epidemiological data of tumours in this area in our environment is scarce. This study was done to ascertain the histopathologic pattern of tumours in the posterior cranial fossa in a predominantly black population. Method: A ten-year retrospective study of histologically diagnosed posterior cranial fossa tumours seen in our hospital facility was done. A total of 72 cases in which neurosurgical intervention was carried out were identified and this included all age groups. The age, sex, site of tumour and histological diagnosis were extracted from the patients' records. Result: Adult patients predominated with 55.6% while the paediatric patients were 44.4%. The male to female ratio in the paediatric patients was 2.56:1 but the ratio was equal in the adult patients. WHO grade 1 tumours were the commonest tumours seen (45.8%) while grade II tumours were the least (4.2%). Medulloblastomas (20.83%), Pilocytic astrocytomas (18.6%) and Meningiomas (8.33%) were the commonest tumours seen. Commonest locations are in the cerebellar hemispheres (56.9%) and the fourth ventricle (13.89%). Conclusion: Our study showed a higher occurrence of Medulloblastomas in contrast to other studies which have shown more of Schwannomas, a tumour type that was rare in this study. The relatively low number of metastatic tumours in this study may be due to lack of presentation of such patients.
Sudden death in giant pituitary adenomas: two case reports with literature review
(Wolters Kluwer - Medknow, 2017) Salami, A.; Babatunde, T.; Ogun, O.; Lawan, A.; Abubakar‑Akanbi, S.; Nweke, M.
Pituitary macroadenomas are rare tumors constituting <1% of intracranial tumors. The giant macroadenomas are even rarer and have the potential to cause fatality due mostly to mass effects within the intracranial space. Most cases are nonfunctional and are either null cell adenomas or gonadotroph adenomas in which symptoms may have been ignored by the patient. Sudden deaths from intracranial tumors are uncommon and pituitary adenomas are very rarely associated with unexpected deaths. Here, we present two cases of giant pituitary adenomas both of which were undiagnosed before demise of the patient. The autopsy report showed no other findings except the sellar tumor. Immunohistochemistry of both tumors showed null cell adenoma