Browsing by Author "Olaogun, S. C."

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A case report of Dystocia due to shistosomus reflexus (conjoined twins) in a West African Dwarf Doe in Ibadan, Nigeria
(Faculty of Veterinary Medicine, University of Ibadan., 2017) Olaogun, S. C.; Abiola J. O.; Jeremiah, O. T.
A three years old light brown West African dwarf doe, weighing about 32 kg was presented with history of dystocia of about 36 hours was presented to the University of Ibadan Veterinary Teaching Hospital, Ibadan. The animal was restless. Close observation showed a swollen vulva with protruding foetal head. There was abnormal slimy blood tinted discharges with foul odour in her vulva. Rectal temperature was 40 degree Celcius with relatively high respiratory rate. Dystocia was diagnosed. Using systematic and calculated tration and retropulsion, Schistosomus reflexus (co-joined twins) were subsequently delivered after about 20 minutes of intervention. Post-manipulation care was given by intramuscular injection of procaine penicillin and streptomycin combination at a dose of 1ml per 10kg body weight for 4 days consecutively; multivitamins injection was also given at 1ml per 10kg body weight for four days. Complete recovery of the doe was achieved.
A cryptic mitochondrial DNA link between North European and West African dogs
(Elsevier, 2017) Adeola, A. C.; Ommeh, S. C.; Song, J. J.; Olaogun, S. C.; Sanke, O. J.; Yin, T. T.; Wang, G. D.; Wu, S. F.; Zhou, Z. Y.; Lichoti, J. K.; Agwanda, B. R.
Domestic dogs have an ancient origin and a long history in Africa. Nevertheless, the timing and sources of their introduction into Africa remain enigmatic. Herein, we analyse variation in mitochondrial DNA (mtDNA) D-loop sequences from 345 Nigerian and 37 Kenyan village dogs plus 1530 published sequences of dogs from other parts of Africa, Europe and West Asia. All Kenyan dogs can be assigned to one of three haplogroups (matrilines; clades): A, B, and C, while Nigerian dogs can be assigned to one of four haplogroups A, B, C, and D. None of the African dogs exhibits a matrilineal contribution from the African wolf (Canis lupus lupaster). The genetic signal of a recent demographic expansion is detected in Nigerian dogs from West Africa. The analyses of mitochondrial genomes reveal a maternal genetic link between modern West African and North European dogs indicated by sub-haplogroup D1 (but not the entire haplogroup D) coalescing around 12,000 years ago. Incorporating molecular anthropological evidence, we propose that sub-haplogroup D1 in West African dogs could be traced back to the late-glacial dispersals, potentially associated with human hunter-gatherer migration from southwestern Europe.
A Retrospective Study of Ruminant Cases Presented Between 1996 and 2005 at the Veterinary Teaching Hospital, University Of Ibadan, Ibadan, Nigeria
(Integrity Research Journals, 2016) Abiola, O. J.; Olaogun, S. C.; Emedoh, O. M.; Jeremiah, O. T.
Retrospective study of ruminant cases (cattle, sheep and goats) presented to the Veterinary Teaching Hospital, University of Ibadan, Ibadan between a period of ten years (January1996 to December 2005) was conducted to determine the most prevalent diseases using clinical case file records. Within the period of study, a total of 601 cases were handled out of which 394 (65.56%) occurred in goats, 171(28.45 %) sheep and 36(5.99%) cattle. The most prevalent infections in the three species were ectoparasitism (31.11%), endoparasitism (16.97%) and reproductive cases (13.31%). Among caprine species, endoparasitism was 27.16%, while ectoparasitism and reproductive conditions had 20.96% and 13.96% respectively. As for ovine species endoparasitism was 38.01% while ectoparasitism 9.94% and reproductive conditions had 9.94. But among bovine species, endoparasitism was 41.67%, reproductive conditions had 22.22% and bacterial diseases had 16.67%. The high prevalence of these conditions may be due to poor management practices, improper health/veterinary care, stress on pregnant animals, and neglect of prophylactic measures for disease prevention. There is therefore need for awareness and education of livestock farmers/owners on effective prevention and control measures through livestock extension services and proper management system that restrict animals from roaming freely thereby preventing injuries caused by trauma.
Analysis of the genetic variation in mitochondrial DNA, Y-chromosome sequences, and MC1R sheds light on the ancestry of Nigerian indigenous pigs
(Springer Nature, 2017) Adeola, A. C.; Oluwole, O. O.; Oladele, B. M.; Olorungbounmi, T. O.; Boladuro, B.; Olaogun, S. C.; Nneji, L. M.; Sanke, O. J.; Dawuda, P. M.; Omitogun, O. G.; Frantz, L.
Background: The history of pig populations in Africa remains controversial due to insufficient evidence from archaeological and genetic data. Previously, a Western ancestry for West African pigs was reported based on loci that are involved in the determination of coat color. We investigated the genetic diversity of Nigerian indigenous pigs (NIP) by simultaneously analyzing variation in mitochondrial DNA (mtDNA), Y-chromosome sequence and the melanocortin receptor 1 (MC1R) gene. Results: Median-joining network analysis of mtDNA D-loop sequences from 201 NIP and previously characterized loci clustered NIP with populations from the West (Europe/North Africa) and East/Southeast Asia. Analysis of partial sequences of the Y-chromosome in 57 Nigerian boars clustered NIP into lineage HY1. Finally, analysis of MC1R in 90 NIP resulted in seven haplotypes, among which the European wild boar haplotype was carried by one individual and the European dominant black by most of the other individuals (93%). The five remaining unique haplotypes differed by a single synonymous substitution from European wild type, European dominant black and Asian dominant black haplotypes. Conclusions: Our results demonstrate a European and East/Southeast Asian ancestry for NIP. Analyses of MC1R provide further evidence. Additional genetic analyses and archaeological studies may provide further insights into the history of African pig breeds. Our findings provide a valuable resource for future studies on whole-genome analyses of African pigs.
Antibiotic sensitivity of some bacteria isolates isolated from scouring calves from some farms in Oyo and Ogun States, Nigeria
(Faculty of Veterinary Medicine, University of Ibadan, Nigeria, 2018) Olaogun, S. C.; Jeremiah, O. T.; Jubril, A. J.
Diarrhoea in young pre-weaned calves is one of the most important causes of calf morbidity and mortality. Information on this multi-aetiological condition is scanty in Nigeria. Therefore, we studied the prevalent bacteria and antibacteria susceptibility to various bacterial isolates from faecal samples of suspected cases of calf scours in Oyo and Ogun States of South-western Nigeria. One hundred and twenty calf faecal samples (120) from various breeds of cattle showing clinical manifestation of scours were screened for bacterial agents in two farms in Oyo and five farms in Ogun States. Isolation and identification were done using standard procedures, while antibiotic sensitivity was done using Kirby Bauer's disc diffusion method. Escherichia coli, Salmonella spp. and Campylobacter spp. were identified. Out of all the calves, 19 calves (15.8%) were positive for bacteria agents, E. coli was isolated from 12 calves (10%), Salmonella spp. was isolated in 10 calves (8.3%) and Campylobacter spp. was isolated in 1 calf (0.8%). Antibiotic sensitivity test revealed that the most sensitive antibiotics were Meropenem (91.3%) and Amikacin (82.6%) while the least sensitive was Ampicillin (21.7%). Therefore Meropenem is the most sensitive antibiotic and recorded the highest percentage sensitivity in all the three bacteria pathogens isolated, while Ampicillin appeared to be the least sensitive antibiotic to virtually all the pathogens isolated. Meropenem is therefore recommended as the drug of choice for the management of bacteria calf scours. The isolation of highly pathogenic E.coli 0157 from calf scour cases reaffirmed cattle as a reservoirs host which may enter the food chain and poses a faeco-oral potential public health hazards.
Antibiotic sensitivity of some bacteria isolates isolated from scouring calves from some farms in Oyo and Ogun States, Nigeria
(Faculty of Veterinary Medicine, University of Ibadan, Nigeria, 2018) Olaogun, S. C.; Jeremiah, O. T.; Jubril, A. J.
Diarrhoea in young pre-weaned calves is one of the most important causes of calf morbidity and mortality. Information on this multi-aetiological condition is scanty in Nigeria. Therefore, we studied the prevalent bacteria and antibacteria susceptibility to various bacterial isolates from faecal samples of suspected cases of calf scours in Oyo and Ogun States of South-western Nigeria. One hundred and twenty calf faecal samples (120) from various breeds of cattle showing clinical manifestation of scours were screened for bacterial agents in two farms in Oyo and five farms in Ogun States. Isolation and identification were done using standard procedures, while antibiotic sensitivity was done using Kirby Bauer's disc diffusion method. Escherichia coli, Salmonella spp. and Campylobacter spp. were identified. Out of all the calves, 19 calves (15.8%) were positive for bacteria agents, E. coli was isolated from 12 calves (10%), Salmonella spp. was isolated in 10 calves (8.3%) and Campylobacter spp. was isolated in 1 calf (0.8%). Antibiotic sensitivity test revealed that the most sensitive antibiotics were Meropenem (91.3%) and Amikacin (82.6%) while the least sensitive was Ampicillin (21.7%). Therefore Meropenem is the most sensitive antibiotic and recorded the highest percentage sensitivity in all the three bacteria pathogens isolated, while Ampicillin appeared to be the least sensitive antibiotic to virtually all the pathogens isolated. Meropenem is therefore recommended as the drug of choice for the management of bacteria calf scours. The isolation of highly pathogenic E.coli 0157 from calf scour cases reaffirmed cattle as a reservoirs host which may enter the food chain and poses a faeco-oral potential public health hazards.
Antibiotic sensitivity of some bacteria isolates isolated from scouring calves from some farms in Oyo and Ogun States, Nigeria
(Faculty of Veterinary Medicine, University of Ibadan, Nigeria, 2018) Olaogun, S. C.; Jeremiah, O. T.; Jubril, A. J.
Diarrhoea in young pre-weaned calves is one of the most important causes of calf morbidity and mortality. Information on this multi-aetiological condition is scanty in Nigeria. Therefore, we studied the prevalent bacteria and antibacteria susceptibility to various bacterial isolates from faecal samples of suspected cases of calf scours in Oyo and Ogun States of South-western Nigeria. One hundred and twenty calf faecal samples (120) from various breeds of cattle showing clinical manifestation of scours were screened for bacterial agents in two farms in Oyo and five farms in Ogun States. Isolation and identification were done using standard procedures, while antibiotic sensitivity was done using Kirby Bauer's disc diffusion method. Escherichia coli, Salmonella spp. and Campylobacter spp. were identified. Out of all the calves, 19 calves (15.8%) were positive for bacteria agents, E. coli was isolated from 12 calves (10%), Salmonella spp. was isolated in 10 calves (8.3%) and Campylobacter spp. was isolated in 1 calf (0.8%). Antibiotic sensitivity test revealed that the most sensitive antibiotics were Meropenem (91.3%) and Amikacin (82.6%) while the least sensitive was Ampicillin (21.7%). Therefore, Meropenem is the most sensitive antibiotic and recorded the highest percentage sensitivity in all the three bacteria pathogens isolated, while Ampicillin appeared to be the least sensitive antibiotic to virtually all the pathogens isolated. Meropenem is therefore recommended as the drug of choice for the management of bacteria calf scours. The isolation of highly pathogenic E.coli 0157 from calf scour cases reaffirmed cattle as a reservoirs host which may enter the food chain and poses a faeco-oral potential public health hazards.
Antibiotic sensitivity of some bacteria isolates isolated from scouring calves from some farms in Oyo and Ogun States, Nigeria
(Faculty of Veterinary Medicine, University of Ibadan, Nigeria, 2018) Olaogun, S. C.; Jeremiah, O. T.; Jubril, A. J.
Diarrhoea in young pre-weaned calves is one of the most important causes of calf morbidity and mortality. Information on this multi-aetiological condition is scanty in Nigeria. Therefore, we studied the prevalent bacteria and antibacteria susceptibility to various bacterial isolates from faecal samples of suspected cases of calf scours in Oyo and Ogun States of South-western Nigeria. One hundred and twenty calf faecal samples (120) from various breeds of cattle showing clinical manifestation of scours were screened for bacterial agents in two farms in Oyo and five farms in Ogun States. Isolation and identification were done using standard procedures, while antibiotic sensitivity was done using Kirby Bauer's disc diffusion method. Escherichia coli, Salmonella spp. and Campylobacter spp. were identified. Out of all the calves, 19 calves (15.8%) were positive for bacteria agents, E. coli was isolated from 12 calves (10%), Salmonella spp. was isolated in 10 calves (8.3%) and Campylobacter spp. was isolated in 1 calf (0.8%). Antibiotic sensitivity test revealed that the most sensitive antibiotics were Meropenem (91.3%) and Amikacin (82.6%) while the least sensitive was Ampicillin (21.7%). Therefore Meropenem is the most sensitive antibiotic and recorded the highest percentage sensitivity in all the three bacteria pathogens isolated, while Ampicillin appeared to be the least sensitive antibiotic to virtually all the pathogens isolated. Meropenem is therefore recommended as the drug of choice for the management of bacteria calf scours. The isolation of highly pathogenic E.coli 0157 from calf scour cases reaffirmed cattle as a reservoirs host which may enter the food chain and poses a faeco-oral potential public health hazards.
Bovine Helminthosis: Blood Glucose Levels and Age Influence on Susceptibility in Some Nigerian Breeds of Cattle
(Science Domain, 2015) Olaogun, S. C.; Lasisi, O. T.
The effect of natural bovine helminthosis on blood glucose levels and the influence of age on its susceptibility were studied in four breeds of cattle in Ibadan Nigeria, using abattoir samples. One hundred and twenty cattle (28 males and 92 females) comprising Sokoto Gudali (51),White Fulani (30), Red Bororo (24) and Kuri (15) breeds of cattle which were all above 2.5 years old were used for this study. The blood glucose levels of all the cattle were determined by spectrophotometric method using Randox kitR (Randox LaboratoriesLimited, United Kingdom) while the corresponding fecal samples were examined for the helminth burden using the modified McMaster technique. The age of each cattle was estimated using a standard dentitition technique. The data obtained were subjected to Analysis of Variance (ANOVA) and Correlation analysis. Significance was determined at p< 0.05. Sokoto Gudali breed was the least susceptible (21.56%) to natural helminthosis while Kuri breed was the most susceptible (26.67%). Cattle in age range of 2.5-3years were the most susceptible to natural helminthosis across all the breeds, while cattle older than 3 years were less susceptible. Blood glucose had positive correlation with age (r = 0.24) and negative correlation with helminth burden (r = -0.14). Hypoglycemia was prominent in all the cattle with heavy helminth burdens. Female cattle showed a significantly higher susceptibility to natural helminthosis than males. This study identifies natural helminthosis as a predisposing factor to hypoglycemia in Nigerian breeds of cattle which is observed to be more severe in younger cattle.
Calf Diarrhea: Epidemiological Prevalence and Bacterial Load in Oyo and Ogun States, Nigeria
(Alexandria Journal of Veterinary Sciences, 2016) Olaogun, S. C.; Jeremiah, O. T.; Jubril, A. J.; Adewuyi, O. O.
Diarrhea in calves is one of the most important causes of calf morbidity, mortality and economic losses. The prevalence of diarrhea in calves was studied in 12 farms in Oyo and Ogun states in South Western Nigeria. A total of 825 calves up to 6-months old were sampled over a period of 12 months with 120 (14.5%) of the calves showing signs of diarrhea. Faecal samples of diarrheic calves (n=120) were collected, and screened for bacterial pathogens using standard laboratory procedures. In Oyo and Ogun States, highest prevalence rates of calves with diarrhea were noticed in two farms of Oyo State 50% (25 out of 50 calves) and Ogun State 23% (12 out of 52 calves) were recorded respectively. Only 19 (15.8%) of the 120 calves had bacterial pathogens; Of the calves (n=19) where bacteria were isolated Escherichia coli was isolated from 12 calves (63.2%), Salmonella species was isolated from 10 calves (52.6%) and Campylobacter species was isolated from 1 calf (5.3%). The lowest levels of bacterial detection were seen in diarrheic samples from White Fulani calves (8.9%) with the highest levels seen in samples from Jersey calves (50%). Calves of 0-2 months had positivity bacterial cause of diarrhea of 18.4%, calves between 3 and 4 months had positivity of 8.8% and calves of 5-6 months had positivity of 20%. Bull calves had 17.0% positivity while heifers had 14.8% positivity among diarrheic calves. Calves having severe diarrhea had highest percentage positivity (26.1%) of bacterial isolates while calves with moderate diarrhea had the least percentage positivity (13.6%). Calves reared in semi-intensive system of management were the most susceptible (18.0%) while those reared under extensive system were least susceptible (13.6%) to bacterial scours. Therefore, Escherichia coli, Salmonella and Campylobacter organisms were most prevalent in calf scours. Age, breeds, sex, severity of diarrhea and system of management are predisposing factors of calf diarrhea.
In-vitro dissolution and some physical properties of two generics of levamisole blous formulations for large animals.
(Indo American Journal of Pharmaceutical Research (IAJPR) Publications, 2017) Gberindyer, A. F.; Omotosho, O. O.; Olaogun, S. C.
Physical and dissolution properties of solid oral dosage formulations significantly affect therapeutic outcomes following their use in veterinary medicine. Therapeutic failure of most levamisole boluses for the prevention and treatment of helminth infections have been a recurrent complaint from animal health workers and veterinarians in Nigeria. However, there is dearth of information on the quality of oral bolus formulations of levamisole for veterinary use in Nigeria. Consequently, the purpose of this study was to evaluate physical and dissolution properties of two generic products of levamisole boluses commonly used in large animal practice in Nigeria. Two frequently used generics of levamisole oral boluses for large animal practice (A & B) were evaluated for bolus weight uniformity, hardness, friability, disintegration and dissolution as specified in the United States Pharmacopoeia. The results demonstrated that generic B failed weight uniformity and friability tests, whereas generic A failed friability and disintegration tests. All the products passed dissolution profile test as specified. Consequently, the two products can be used interchangeably, however, generic B is recommended for treating acute enteric helminthosis because of its fast disintegration and dissolution rates as compared to generic A.
Incidence and biochemical parameters of dermatophilosis in Nigerian cattle breed from livestock markets, Oyo state, Nigeria
(Faculty of Veterinary Medicine, University of Tripoli, Libya, 2018) Olaogun, S. C.; Onwuzuruike, K. J.
Dermatophilosis is one of the major economically important diseases of cattle in Nigeria. Managing the condition has been very challenging and re-occurrence has been reported with moderate to high morbidity and mortality. The incidence and biochemical features of cattle with dermatophilosis was conducted in June to December 2016 across the four geopolitical zones of Oyo state, Nigeria. Clinical diagnosis were made based on appearance of dermatophilosis lesion, breeds morphologically characterized, ageing were based on rostral dentition and severity based on the extent and nature of the lesion. Biochemical analysis was based on standard procedure as prescribed by Fortress International. Fifty cattle were found to be infected with clinical dermatophilosis during the period of the study. Twenty four (48%) in Ibadan zone, 14 (28%) in Oyo/Ogbomosho, 8 (16%) in Oke-ogun and 4 (8%) in Ibarapa zone. Breeds distribution across the zones showed 28 (56%) White Fulani, 5 (10%) Sokoto Gudali, 3 (6%) Adamawa Gudali, 7 (14%) Red Bororo, 5 (10%) Cross breeds while the Kuri was 2 (4%). Regarding animal ages, less than 2 years old were 2 animals (4%) while the adults were 48 animals (96%) and they fall under the categories of 2-2½ years of age, 3-3½ years of age and those which are over 3½ years of age. The different levels of severity were categorized into mild (20 (40%)), moderate (23 (46%)) and severe (7 (14%)) .The best parameters were seen in White Fulani, while the least were seen in Adamawa Gudali. The age group in the category of 3 - 3½ years had most of the best serum values while the least values were seen in animals less than 2 years of age. Cattle exhibiting mild lesions had most of the best serum values and the least values were observed in cattle with severe lesions. No significant difference (p > 0.05) was observed in the mean values for the various parameters studied among the breeds, age, and severity of condition.
Occurrence of Skin Abscess and Sensitivity Pattern of Associated Bacterial Organisms in Pigs on Ifelodun Farm Settlement, Ogun State, Nigeria
(Faculty of Veterinary Medicine, Alexandria University, Egypt, 2016) Omotosho, O. O.; Olaogun, S. C.; Odukaye, A. O.
Pigs are relatively prone to abscess formation especially in the skin. This study was designed to assess the occurrence of skin abscess in pigs on the Ifelodun farm settlement in Ogun state, South-West Nigeria and evaluate the antibiotic sensitivity pattern of bacterial organisms isolated from pus samples from the abscesses. A total of 2,909 pigs from 104 randomly selected farms on the Ifelodun farm settlement were physically examined. The anatomic locations of gross swellings on the skin were noted. Diagnosis of skin abscess was arrived at after palpation and aspiration of content. Pus samples from 14 intact abscesses were collected aseptically for isolation and sensitivity using standard cultural and disc diffusion method respectively. Data were analysed using descriptive statistics. 26 (0.89%) of the 2,909 pigs examined across 22 (21.2%) farms out of 104 farms surveyed were affected. The anatomic distribution of the abscesses includes 43.3%, 6.67%, 16.67% and 33.33% on the neck, forelimbs, trunk, and hind limbs respectively. None was observed on the head. 10 bacterial species were isolated from the 14 tested isolates with Arcanobacterium pyogenes (57.1%), Staphylococcus aureus (42.8%) and Escherichia coli (35.7%) being most frequently isolated. Antibiotic sensitivity profile varied with more isolates being sensitive to Erythromycin, Tetracycline, Gentamicin, and Chloraphenicol for gram positive bacterial species and Ceftazidine, Cefuroxime, Gentamicin and Augmentin for gram negative species. Swine skin abscess affects various body regions in pigs on Ifelodun pig farm settlement. The neck and hind limbs were mostly affected likely due to poor injection practices. Based on availability of veterinary preparation readily available in the Nigerian market, Gentamicin, Tetracycline and Erythromycin remain viable options for post-surgical management of the abscesses while Chloramphenicol should be avoided due to its deleterious effect on humans. Antibiotic sensitivity is recommended in cases of recurring skin abscesses in a pig or herd.
Perception of Rabies among Residents of Selected Local Government Areas of Oyo State, Nigeria
(Science Domain International, 2016) Adejumobi, O. A.; Omobowale, O. C.; Olaogun, S. C.; Omobowale, T. O.; Nottidge, H. O.
"Rabies, a fatal neurotropic disease of man and animals is usually a neglected disease in many parts of the world probably because of the erroneous belief that it affects animals predominantly. This study was designed to investigate the knowledge and attitude of people in selected communities of Oyo State, Nigeria with the aim of assessing the possible risk of getting infected with the virus. A total of 323 participants were randomly selected from 10 local government areas of Oyo State, Nigeria and interviewed using a pre-tested structured questionnaire. The results were analysed using descriptive statistics and Pearson’s chi square method. Information obtained included the demographic characteristics of the participants, their interaction with dogs, knowledge about rabies and its fatality, its mode of transmission and prevention as well as the perception of and attitude of people towards rabies. Of the 323 participants, 180(55.8%) were male while 143(44.3%) were female, 115(47.7%) were Christians, 123(51%) were muslims and 3(1.2%) were traditional religion adherents. Furthermore, 263(81.4%) had different levels of education 60(18.6 %) were illiterate, 119(36.8%) used to own dog while only 54(16.4%) presently kept dogs for reasons which included hunting 16(30.1%), security 28(52.8%), breeding {3(5.66%)} and as companionship 6(11.3%). Greater number (80%) lived in the rural areas while 62(19.6%) were urban dwellers. Out of the 323 participants, 256 (79.5%) knew about rabies, of these, 46(18%) heard about the disease from awareness campaigns, 11(4.3%) heard from human and veterinary hospitals 58(22.7%) heard from interpersonal interactions while 123(48.1%) knew by personal experiences. From the people that claimed knowledge, 231(90.2%) knew that rabies was a fatal disease, 96(37.5%) knew about rabies in other animal species aside dogs, 110(43%) knew about rabies transmission by dog or cat bite, 24(9.4%) knew that rabies can be transmitted by wild animals. Also, 130(50.8%) claimed knowledge of rabies prevention in animals but 88(34.4%) only knew about antirabies vaccination.in animals. Similarly, 128(50%) claimed knowledge of rabies prevention in man and of these, 38(14.8%) recommended prophylactic and post exposure antirabies vaccination, 42(16%) hospital visits, 20(7.8%) dog elimination and staying away from dogs, while 12(4.7%) recommended religious means, and use of herbs. When asked about first aid treatment, 99(38.7%) suggested wound washing with soap and antiseptic, 171(66.8%) recommended hospital visit while 40(15.6%) suggested a visit to the herbalist for the antidote. Pearson’s chi square showed significant difference (P<0.05) in the knowledge of the respondents and marital status. Poor knowledge of some aspects of rabies and negative attitude of dog owners towards rabies may portend grave public health consequences.
Whole-genome sequencing of African dogs provides insights into adaptations against tropical parasites
(Oxford University Press, 2018) Yan-Hu, L.; Wang, L.; Tao Xu,T.; Guo, X.; Adeniyi C.; Adeola, O. J.; Olaogun, S. C.
Natural selection in domestic dogs is of great interest in evolutionary biology since dogs havemigrated to every inhabited continent of the world alongside humans, and adapted to diverse environments. Here, we explored their demographic history and genetic basis of adaptation to the tropical African environment using whole genome analyses of 19 African indigenous dogs from Nigeria. Demographic analysis suggests that the ancestors of these dogs migrated into Africa from Eurasia 14,000 years ago and underwent a severe founder effect before population expansion. Admixture analysis further reveals that African dog genomes contain about 1.88–3.50% introgression from African golden wolves (Canis anthus). Population genetic analysis identifies 50 positively selected genes linked with immunity, angiogenesis, ultraviolet protection, as well as insulin secretion and sensitivity that may contribute to adaptation to tropical conditions. One of the positively selected genes, adhesion G protein-coupled receptor E1 (ADGRE1), has also been found to be association with severe malaria resistance in African human populations. Functional assessments showed that ADGRE1 provides protective host defense against Plasmodium infections. This result, together with the fact that the inflammatory response to canine babesiosis is similar to complicated falciparum malaria in humans, support the dogs as a model for the study of malaria control and treatment.