Pharmacognosy
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Item Effect of ethanol extract of Irvingia Gabonensis (Aubrey Lecomte Ex O. Rorke) baill. (Irvingiaceae) seeds on diet induced obesity in Wistar Rats(Istanbul Medipol University, 2021) Ajayi, T. O.; Bakre, A. G.; Akintayo, T. C.; Bamigboye, O. O.Obesity is a chronic condition associated with high morbidity and mortality rates. Its comorbidities include cancer, diabetes mellitus, and cardiovascular diseases. Traditional medicines have found increasing use due to cost effectiveness and mini mal side effects. This study evaluated the Anti-obesity effect of ethanolic extract of Irvingia gabonensis seeds. Wistar rats were divided into control and treatment groups. Untreated group I on normal diet (negative control), untreated group II on high fat diet (HFD) and 10 mL/Kg Tween 80 (positive control), extract treated groups III-V (50, 100 and 200 mg/Kg) on HFD. Orlistat treated group VI (200 mg/Kg) on HFD (standard). Body mass index (BMI), weight of abdominal fat, cholesterol levels and hepatic enzymes were evaluated after 12 days of treatment. Body mass index (BMI) and abdominal fat of (treatment groups) reduced. How ever, the seed extract and orlistat did not significantly increase liver enzymes. Conclusion: Irvingia gabonensis seed extract showed anti-obesity properties.Item Lipid altering potential of moringa oleifera lam seed extract and isolated constituents in Wistar rats(Ibadan Biomedical Communications Group, 2020) Ajayi, T. O.; Moody, J. O.; Odumuwagun, O. J.; Olugbuyiro, J. A. O.The use of natural products have become popular because of their minimal adverse effect, cost effectiveness and accessibility. Moringa oleifera, is a valued plant that has found use ethnomedicinally and economically. The leaves have been investigated in various researches for different activities. This study is aimed at evaluating the seeds for its serum lipid profile altering activities in animal models. Five groups of five animals (120-150 g) per group were made obese by feeding with a high fat diet (HFD) for 10 weeks. The basal lipid profile was determined, and treatment commenced with methanol extracts of Moringa oleifera seed (MOSE) at 100 and 200 mg/kg b w for 6 weeks. Control groups were the Orlistat treated (50 mg/kg b w), untreated and normal diet groups. The antihyperlipidemic activity in-vivo and an enzyme anti lipase assay in-vitro were determined respectively. The characterisation of isolated compounds and derivative was by spectroscopic techniques. A significant decrease in Very Low Density Lipoprotein cholesterol (VLDLc) at p< 0.01 was observed across the five groups when compared with the standard Orlistat. A significant increase in High Density Lipoprotein cholesterol (HDLc) at p< 0.01 was observed in the group treated with 200 mg/kg MOSE. However, a dangerous significant increase in Athereogenic index (AI) was observed in the group treated with 100mg/kg MOSE The derived 4- acetyl benzylisothiocyanate-O –α-L rhamnopyranoside (2) from isolated 4- hydroxybenzylisothiocyanate-O-α-L rhamnopyranoside (1) revealed the highest activity of 99.17% at 0.5 mg/mL. The methanol extract of Moringa oleifera seed could alter lipid profile and a structure activity relationship was observed with respect to the isolated compound and its derivatized analogue.