Akin-Ajani, O. DAjala, T. OOkoli, U. M.Okonta, O2026-03-0920182636‑8552ui_art_akin-ajani_development_2018Acta Pharmaceutica Sciencia 56(3) P.7 – 25https://repository.ibadanedu.com/handle/123456789/13260The objective of this study was to harness the excipient potential of date mucilage by co-grinding and co-fusing with avicel for enhanced performance in the directcompression of metronidazole. Co-grinding and co-fusing of parent polymers were done using established methods and excipients were used in the direct-compression of metronidazole tablets. The shape and surface morphology of the particles of date mucilage (DAM) and co-processed excipients were generally granular, rough and irregular. There was a significant improvement in the disintegration of tablets prepared using the coprocessed excipients in comparison to that prepared using DAM alone. The disintegration time for tablets prepared using co-fused excipients was lower than that of co-grinded additives although the differences were not significant (p > 0.05). Generally, the co-processed excipients improved the mechanical and disintegration properties of the tablets produced compared to tablets prepared using DAM alone and could be further developed as direct compression excipientsenDate mucilageavicelco-processingmetronidazole tablets.Article