Artistic Works
Permanent URI for this collectionhttps://repository.ibadanedu.com/handle/123456789/317
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Item Development of a visible spectrophotometric method for the assay of Methyldopa following oxidative coupling with N-(1-naphthyl) ethylenediamine dihydrochloride(Nigeria Association of Pharmacists in Academia, 2015) Thomas, O. E.; Mustapha, A. K.Background: Methyldopa is a centrally acting hypertensive drug that remains one of the choice treatment options in the management of hypertension in pregnancy and during surgical anaesthesia. Although a number of methods of analysis are available, most employ sophisticated techniques and strict experimental conditions. Objective: To develop and validate a simple visible spectrophotometric analysis for the quantitative determination of methyldopa in bulk and dosage forms. Method: The method was based on the oxidative coupling reaction between methyldopa and N-(1-naphthyl) ethylenediamine (Bratton-Marshall’s reagent) to generate a blue chromogen. Reactions variables critical to optimal response were established. Various analytical and validation parameters including repeatability, reproducibility and selectivity were also determined. Results: The calibration graph was linear between 30 and 80 μg/ml at 580 nm with a correlation coefficient of 0.9996. The apparent molar absorptivity was 1.52 ×103 L mol−1 cm−1 while the limits of detection and quantification were 9.3 and 31 μg/ml respectively. The method was accurate and precise with recovery in the range of 99.26-101.30 % and intra- and inter-day precision (%RSD) at three different concentrations less than 1.0%. When applied to the analysis of dosage form, there was no statistical difference between the new method and the official method. There was no interference from commonly used excipients. Conclusion: The method is rapid, simple and cost-effective. It can serve as a reliable and affordable assay method for the routine analysis of methyldopa in bulk and dosage formsItem External debt and Economic Growth: the Nigeria Experience(European Centre for Research Training and Development UK, 2016) Nwannebuike, U. S.; Ike, U. J.; Onwuka, I. O.This research work was aimed at ascertaining the impact of external debt on economic growth in Nigeria. Ex-post facto research design was adopted for the study. While data on Gross Domestic Product (GDP), External Debt Stock and External Debt Service Payment were obtained from World Bank International Debt Statistics, Exchange Rate data were collected from Central Bank of Nigeria Statistical Bulletin, 2013. The period of study was 1980-2013. Model was formulated and data were analyzed using Ordinary Least Square. Diagnostic tests were conducted using Augmented Dick Fuller Unit Root Test, Co-integration and Error Correction Model. The independent variable was GDP, while the explanatory variables were External Debt Stock, External Debt Service Payment and Exchange Rate. We discovered that External Debt had a positive relationship with Gross Domestic Product at short run, but a negative relationship at long run. Also, while External Debt Service Payment had negative relationship with Gross Domestic Product, Exchange Rate had a positive relationship with it. The paper concluded that exchange rate fluctuation had positive impact on the Nigerian economy while external debt stock and debt service payment had negative impact on the same economy. The study recommended amongst others, that Debt Management Office should set mechanism in motion to ensure that loans were utilized for purposes for which they were acquired as well as set a ceiling for borrowing for states and federal governments based on well-defined criteria.