FACULTY OF BASIC MEDICAL SCIENCES

Permanent URI for this communityhttps://repository.ibadanedu.com/handle/123456789/262

Browse

Author: search.filters.author.Adeoye, A. O.

Search Results

Now showing 1 - 2 of 2
  • Thumbnail Image
    Item
    Postmortem Heart Weights and Valvular Circumference of Apparently Healthy Adult Nigerian Decedents - an Observational Study
    (The Brazilian Society of Anatomy (SBA), 2022) Ezenkwa, U. S.; Salami, A. A.; Adeoye, A. O.; Ogunbiyi, O. J.
    Introduction: Organ weights at postmortem examination of deceased Nigerians are compared with those of Caucasians to determine pathologies and cause of death. Indigenous data are needed because of differences in race and lifestyle. Materials and Methods: This was an eleven-year retrospective study. Postmortem findings and summarized clinical notes of deceased Nigerians archived in the Department of Pathology, University College Hospital, Ibadan, from January 1, 2008 to December 31, 2018 were reviewed. Inclusion criteria were age 18–70 years, traumatic or sudden unexpected death with no pathology in the heart, and no history or postmortem features of hypertension. Data on age, gender, cause of death, body length, heart weights, heart valve circumferences, and ventricular wall thickness were retrieved. Descriptive statistics, Student’s t-test, and regression analysis were performed using SPSS version 20. Confidence limits were set at p < 0.05. Results: Eighty-five cases fulfilled the criteria, comprising 64 males and 21 females, with mean ages of 39.1 ± 13.8 years and 37.2 ± 11.0 years, respectively. The mean heart weights for males and females differed significantly, with means of 310.8 ± 40.3 g (220–405 g) and 261.3 ± 34.0 g (200–325 g), respectively (p < 0.0001). The mean body lengths also differed significantly, with males at 1.70 ± 0.1 m and females at 1.62 ± 0.1 m (p < 0.002). There was no significant difference in age between males and females (p > 0.05). Multiple regression analysis suggested that only gender was a likely predictor of heart weight (p < 0.001). The mean circumferences of the tricuspid, mitral, pulmonary, and aortic valves were 11.2 cm, 9.3 cm, 7.2 cm, and 6.4 cm, respectively, while the mean left and right ventricular wall thicknesses were 1.3 cm and 0.3 cm, respectively. Conclusion: Heart weights and valvular circumferences of apparently healthy adult Nigerians differ by gender and show ranges beyond values reported in other populations. These findings highlight the need for locally derived nomograms for postmortem assessments.
  • Thumbnail Image
    Item
    Diagnostic accuracy of tru-cut biopsy of breast lumps at University College Hospital, Ibadan.
    (College of Medicine, University of Ibadan, 2015) Oluwasola, A. O.; Adeoye, A. O.; Afolabi, A. O.; Adeniji-Sofoluwe, A. T.; Salami, A.; Ajani M. A.; Ogundiran, T. O.; Obajimi M. O.
    Tru-cut needle biopsies form an integral part of Triple assessment of breast cancer and include clinical assessment, mammography and core needle biopsy. No study has been done to evaluate the validity o f the procedure in our environment. This study was done to evaluate the validity of core needle biopsies in our centre. Method'. A retrospective study of patients with tru-, cut needle biopsies of breast lumps and follow-up excisional biopsy or m astectomy done in the Department of Surgery, University College Hospital, Ibadan over a ten year period was done. Fifty one patients who fulfilled the inclusion criteria had their records obtained from the Department of Pathology. The diagnosis was classified into benign and malignant with the excisional biopsy or mastectomy diagnosis used as the gold standard. The sensitivity, specificity and accuracy were calculated and kappa was also done to evaluate the degree of agreement. Results'. A total of 51 cases were included in this study. The average age o f the patients was 47±13years with a range from 19 to 81 years. Thirty of the biopsies (59%) had a definitive diagnosis of malignancy while twenty one (41%) were benign. The overall sensitivity, specificity and accuracy were 86%, 71% and 80.4% respectively. The specificity of malignant biopsies was 68% while benign was 35%. The level of agreement for malignant biopsies was higher than benign biopsies with a kappa of 0.39 for malignant diagnosis as against 0.29 for benign. C onclusion: T ru-cut needle biopsies have a comparable sensitivity and specificity to excisional biopsies. Diagnostic accuracy can be further enhanced with the adoption of image guided biopsies.